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In this current trial with four participants enrolled, intracranial electroencephalography (iEEG) electrodes are implanted in the brain of a person with obesity suffering from loss of control eating, similar to the devices used to study and treat drug-resistant epilepsy and Parkinsons disease

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GLP-1 receptor activation slows gastric emptying, reduces appetite through hypothalamic signaling, and enhances insulin secretion in response to food