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The titration schedule starts at 2 mg per week for 4 weeks, escalates to 4 mg for weeks 5 through 8, then to 8 mg for weeks 9 through 12, and reaches the 12 mg maintenance dose at week 13 (Jastreboff et al., NEJM 2023)
European Journal of Pharmacology , 835, 121-139
The oral diabetes medication canagliflozin (Invokana) is also based on this mechanism (Sarnoski-Brocavich 2013
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