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In 2014, the FDA approved the first of these drugs specifically for weight loss for people with a BMI of 30 and above or a BMI of at least 27 with one weight-related comorbid disease, which affects more than half the U.S

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[5] [6] Observational studies show mixed results, with some suggesting a modest association and others finding no significant relationship after adjusting for confounding factors

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Chronically elevating circulating ketones can reduce cardiac inflammation and blunt the development of heart failure