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Clinical trials have shown that dual agonists significantly reduce hepatic fat and NASH progression

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Mitochondrial quality control system Mitochondria are particularly vulnerable to stress-induced dysfunction, prompting cells to evolve sophisticated quality control systems that detect, repair, or remove damaged mitochondria and misfolded proteins [66, 67]

This imbalance leads to an increase in fat mass due to the expansion and transformation of adipose-derived stem cells, changes in cell shape, and gene activity [29]