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The development of GLP-1 receptor agonists for type 2 diabetes was contextualised within the broader research landscape, including orally bioavailable agonists, allosteric modulators, and unimolecular multi-agonists all of which use the native GLP-1 receptor as their primary target
Marx N, Federici M, Schtt K, et al
Many researchers believe that aging is actually caused by free radical damage and that depleted glutathione levels might be responsible for oxidative damage to our DNA. Levels tend to drop after age 45, a correlation that might explain the cellular damage we can blame for making us feel older
Semaglutide (Ozempic, Wegovy) is a GLP-1 receptor agonist, while Tirzepatide (Mounjaro, Zepbound) binds with both receptors (GLP-1 and GIP) and thus tends to have more effects on weight loss than semaglutide alone
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