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Biopsies from antrum and corpus were taken for DNA and RNA extraction

Thiazolidinediones (TZDs) and neuroprotection TZDs, including pioglitazone and rosiglitazone (which are often referred to by the broader term thioglitazones [TZDs]), are a class of medications primarily used to treat type 2 diabetes

Histopathologically, leukoplakia shows loss of polarity with impaired maturation in the lower epithelial layers, increased cellular and nuclear size, and a sharply demarcated transition from the surrounding normal mucosa (Fig