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Cardiovascular risk-reduction indications, for example, are based on dedicated outcomes trials for certain agents rather than assumed as a universal class effect

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doi: 10.3389/fendo.2025.1734549 Received 28 October 2025 Revised 15 December 2025 Accepted 22 December 2025 Published 15 January 2026 Volume 16 - 2025 Edited by Toshiki Otoda, Nihon University School of Medicine, Japan Reviewed by Zaiyong Zheng, Southwest Medical University, China Akash Batta, Dayanand Medical College & Hospital, India Updates Copyright 2026 Alrasheed, Mostafa, Madkhali and Khairy

CJC-1295 signals the anterior pituitary to produce GH Co-administration with ipamorelin enhances GH release due to their complementary mechanisms of action