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(2023) observed ParaBacteroides depletion rather than enrichment, suggesting exposure timing or generation-dependent effects

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References: FDA Clarifies Policies for Compounders as National GLP-1 Supply Begins to Stabilize FDA Updates Guidelines Compounding Tirzepatide Injections as GLP-1 Shortage Ends Compounded GLP-1 by ForHers FDA Affirms Tirzepatide Shortage Resolved, Sets Transition Period for Compounding FDA Confirms Tirzepatide Shortage Over, Compounders on Borrowed Time FDA Says Eli Lilly Weight Loss Drug Shortage Taking Second Look FDA ZepBound Shortage Impact on Compounding Pharmacies, Patients FDA GLP-1s Weight Loss Drugs Compounding Law Update

And on product safety: FY 2025 saw 317 drug-recall events , most classified as Class II (moderate risk but still serious), per the RAPS report