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Together, Marks argues, this work 'established beyond any doubt, the hormonal nature of glucagon even though no endocrinological disease had yet been identified as a result of its over or under secretion' (Marks 2018)
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However, FXR activation decreases both proglucagon mRNA levels and GLP-1 secretion in response to glucose [175, 176]
Hepokoski, M
Research indicates that individuals with cognitive impairment exhibit impaired neural reserve, reduced neural plasticity, dysfunction in key neurotransmitter systems (e.g., the cholinergic system), and exhausted compensatory mechanisms
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