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For in-clinic injections, experienced staff administer injections with 25 to 30 gauge needles and site rotation to prevent fibrosis

To reach into tougher muscle tissue, the needle may be a bit longer and wider and may be more uncomfortable than a subcutaneous injection

In one study, participants lost about 1.3 kilograms more than placebo in 16 days, and the drug reduced daily caloric intake by roughly 400 calories per day, suggesting appetite suppression via melanocortin-4 receptor (MC4R) activation

doi: 10.1210/en.2011-0195 85 SiuciakJAMcCarthySAMartinANChapinDSStockJNadeauDMet al

Three factors determine results: product quality, protocol consistency, and patience