injectable glp 1 vs oral GLP-1s and GLP-1s may target similar pathways, but they are not identical experiences. Some patients love oral options because they fit more naturally into a daily routine and avoid injections Comparing Oral vs. Injectable Semaglutide

2.2 GIPR agonism serves to reduce GLP-1R mediated GI AEs in the clinic Treatment with GLP-1R agonists can drive nausea, diarrhea, vomiting, and constipation, which often results in discontinuation of treatment (6-10% of patients) or reduction in dose (~15% of patients) (63)

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