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Because copper complexes are photosensitive and hygroscopic (moisture-absorbing), vials must be: Shielded from light (both UV and visible light accelerate copper reduction) Tightly sealed to prevent air and moisture exposure Stored in dark, airtight containers Protected from repeated temperature fluctuations Reconstituted Solutions Once reconstituted with bacteriostatic water, the solution should appear clear and deep blue

2 Bridging factors connecting autophagy and Nrf2-Keap1 pathway Both autophagy dysfunction and oxidative stress have been implicated in many diseases

Analytical methods Cell growth was monitored by measuring OD 600 using a spectrophotometer (OPTIZEN POP, Mecasys, Republic of Korea)

Colloidal anhydrous silica, copovidone, isomalt, magnesium stearate, orange flavour, sodium saccharin, sorbitol, sucralose and talc

The FDA recently approved one of these, elamipretide, for the treatment of a rare genetic mitochondrial disorder