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Prescribing GLP-1s: Evidence, limits, expectations How physicians integrate GLP1s into long-term weight management GLP-1 medications are reshaping the conversation around metabolic health and weight loss but questions remain

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Significant weight loss from GLP-1 therapy may reduce levothyroxine requirements, necessitating regular thyroid function testing every 36 months during active weight loss

The first is metabolic symbiosis between tumor cells: hypoxic cells export lactate and protons via MCT4, while normoxic neighbors import it via MCT1 for oxidative phosphorylation, thereby optimizing intra-tumoral resource utilization [45]