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Additionally, people with multiple weight-related health conditionssuch as type 2 diabetes and hypertensionoften benefit from controlled, gradual activation of GLP-1 signaling to avoid acute changes in blood glucose or blood pressure

[3] It could have efficacy in preventing the development of nitrate tolerance

This finding may be explained by low bioavailability of oral semaglutide in combination with a relatively high degree of variability in exposure after a single dose

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As an indicative example, without its own effect on normal blood pressure, it counteracts L-NAME hypertension as well as L-arginine hypotension (Sikiric et al., 1997a)