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As mentioned above, the link between TNF- and ROS adds another dimension of complexity to the TNF signaling network, as ROS act on numerous proteins required for the regulation of cellular homeostasis, including proteins that mediate cell proliferation, survival, death, differentiation, DNA repair and metabolism 30

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TABLE 5 Pharmacokinetic parameters of BPC157 in dogs following intramuscular administration of doses ranging between 6 and 150 g/kg (mean SD, n = 6)