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Unlike full-length hGH, AOD-9604 does not bind the growth hormone receptor and has shown no measurable effect on IGF-1 levels, glucose homeostasis, or somatic growth in the published preclinical literature
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IFN- serves as a key initiating signal for M1 polarization by binding to IFNGR receptors and activating the JAK/STAT1 pathway resulting in STAT1 phosphorylation and upregulation of effector molecules such as iNOS CD86 and ROS (94, 95)
