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While megadoses of up to 2,000 mcg are considered safe in treating B12 deficiency, its always best to avoid excessive amounts of any vitamin, especially when its not needed

The biggest long-term concern with semaglutide is what happens when you stop

Early data also suggest its benefits for lowering cholesterol levels, liver fat reduction, and cardiovascular health protection

[3] Potency: IC: ~1.01.2 M for NNMT inhibition [1] EC: 2.3 1.1 M (reduction of intracellular 1-MNA levels) [1] Lipogenesis Inhibition: 30 M reduced lipogenesis by 50%

It also has a layer of muscle close to the surface which promotes absorption of B12