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Both IDH1 and IDH2 enzymes utilize NADP + as their cofactor and generate NADPH via oxidative decarboxylation of isocitrate outside the context of the TCA cycle
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Glucose-dependent insulinotropic polypeptide regulates body weight and food intake via GABAergic neurons in mice
Receptor sensitivity decreases with continuous stimulation
Unlike semaglutide which solely activates GLP-1R (one of the three pivotal receptors regulating glucose homeostasis), tirzepatide also activates glucose-dependent insulinotropic polypeptide (GIP) receptor (GIPR) to enhance metabolic benefits with reduced side-effects 5
