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Mechanistically, it has been observed that GSTP1-1 binds, in its monomeric form, both c-Jun and JNK, thus forming an heterotrimeric complex that inhibits the phosphorylation of c-Jun by JNK
The dose is usually defined between 200 and 500 mcg per day
when Rev is provided in trans, cytoplasmic accumulation and post-transcriptional handling of HIV-1 RNA are sensed as a danger signal, activating innate immunity [15, 41, 42]
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