side effects of long term semaglutide use feeling weird on Effects: Short-Term vs. Long-Term Impacts Your Health Ozempic (semaglutide) is commonly used – I am not surprised by

Both are highly effective GLP-1 medications, but Tirzepatide has a dual mechanismit activates both GLP-1 and GIP receptors, which may lead to greater weight loss (up to 22% vs 15-17%)

Weight loss benefits became increasingly documented in clinical trials, leading to expanded indications

Timing consistency allows your GI tract to adapt to a predictable rhythm, which reduces nausea severity over time

Your doctor will monitor your TSH and free T4 at 68 weeks and then 12 weeks after starting semaglutide, and annually thereafter

1 The side effects were consistent with what you'd expect from GLP-1-class drugs: nausea, diarrhea, constipation, and decreased appetite were the most common