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The mechanism by which metformin leads to apoptosis through cell cycle arrest can be explained as follows: when cells are blocked at specific cycle stages, they are unable to complete the normal process of DNA replication and division, resulting in increased intracellular pressure and accumulation of DNA damage, and these changes ultimately trigger the cells apoptosis program (63)
These findings suggest that patients develop diabetes partly by generating fewer functional cells due to cell stress and developmental issues
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Since its still being studied, there arent any official prescribing guidelines yet
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