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6 GLP-1 receptor-positive cells have been identified in human retinal ganglion cells (RGCs), which could suggest a direct protective effect of these medications at the site of damage

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Moreover, the authors also found decreased expression of GLP-1R in an OA rat model, where OA was induced by ACL resection in a transected ACL and medial menisci in the right knee joint [10]

Finally, CKD, including even mild kidney disease, is also associated with increased risk of developing CVD, including HF ( The pathophysiology of HF has been extensively reviewed by others (Metra and Teerlink, 2017

GLP-1 receptor agonists are not currently recommended for use during breastfeeding due to insufficient safety data in lactating populations