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Acetyl-CoA carboxylase (ACC) inhibitors are of interest given that ACC activation promotes lipid storage via stimulation of lipogenesis and inhibition of lipid oxidation.63 Mouse models of ACC inhibitors have shown that these agents can reduce liver triglycerides, but were also noted to increase plasma triglycerides.64 Two ACC inhibitors are currently in phase IIa trials (GS-0976 and PF-05221304).65 Preliminary data from a 12-week clinical phase IIa trial of GS-0976 is available

In such cases, adjusting the dose or switching medications might help 1

Notably, of the first 13 products granted interchangeable status, nine received it without submitting dedicated switching study data, relying instead on comprehensive analytical and clinical pharmacology data

Taking these medications without proper clinical monitoring can lead to side effects or muscle loss

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