Choose a time when you are not under unusual stress, when you have support around you, and when you can focus on your eating and activity
The barrier will still be an investigational new drug application in an FDA designated disease indication (of which for many of these peptide use cases, there isn't one)
The real question, however, is whether that risk reduction can be attributed to the drug or whether the same effects could be achieved with weight loss from other means, such as calorie restriction, exercise, bariatric surgery, etc
Role of vitamin D beyond the skeletal function: a review of the molecular and clinical studies
Weight loss varies between individuals, and people with Hashimotos disease may lose weight more gradually if thyroid hormone levels are not fully optimised