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Fructose stimulates GLP-1 but not GIP secretion in mice, rats, and humans
L-cells are nutrient sensitive and GLP-1 is secreted in response to glucose ( Reference Reimann, Habib and Tolhurst 21 ) , proteins ( Reference Hall, Millward and Long 22 , Reference Power, Conway and McCormack 23 ) peptides ( Reference Hira, Mochida and Miyashita 24 ) , amino acids ( Reference Oya, Kitaguchi and Pais 25 , Reference Reimann, Williams and Silva Xavier 26 ) and lipids ( Reference Lindgren, Carr and Deacon 27 )
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This cascade is mechanistically distinct from that of GHRH analogs, and is the molecular basis for its complementary contribution to growth hormone release
