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Bedioune I, Gandon-Renard M, Dessillons M, Barthou A, Varin A, Mika D, Bichali S, Cellier J, Lechne P, Karam S, Dia M, Gomez S, Pereira de Vasconcelos W, Mercier-Nom F, Mateo P, Dubourg A, Stratakis CA, Mercadier JJ, Benitah JP, Algalarrondo V, Leroy J, Fischmeister R, Gomez AM, Vandecasteele G (2024) Essential role of the RI subunit of cAMP-dependent protein kinase in regulating cardiac contractility and heart failure development

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It works by: Activating GLP-1 receptors in the brain, particularly in areas that regulate appetite and food intake, leading to reduced hunger and increased feelings of fullness Slowing gastric emptying , which prolongs the sensation of satiety after meals Improving insulin secretion in response to food intake and reducing glucagon release, which helps regulate blood glucose levels Promoting weight loss through these combined metabolic effects Wegovy is administered as a once-weekly subcutaneous injection and is primarily broken down by protein degradation pathways rather than through liver enzymes, which reduces the potential for drug-drug interactions

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