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DOE-assisted formulation, optimization, and characterization of tioconazole-loaded transferosomal hydrogel for the effective treatment of atopic dermatitis: in vitro and in vivo evaluation
doi: 10.1038/s41575-019-0173-3 58 MuYMaimaitiyimingRHongJWangYZhaoYLiuRet al
As shown in Figure 3A, the cumulative release of GSH was significantly enhanced in the presence of H 2 O 2 , with the 5 mM H 2 O 2 condition showing the highest release, reaching approximately 100% within 48 h
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For instance, if the activity of superoxide scavenging by SOD2 exceeds the capacity to remove the H2O2 generated, this oxidant can cause oxidative damage or be converted to other ROS
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