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GSH also detoxifies electrophilic xenobiotics compounds (chemical carcinogens, environmental pollutants, drugs, etc.) and their metabolites to GSH adduct (GS-X) in the direct catalysis of glutathione-S-transferase (GST, primary approach) [32]
6 Referncias bibliogrficas: 1 Ballinger A and Peikin SR
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Meanwhile, the expression of iron metabolism-associated genes, including TRFC, FTH1, and FTL, can be modulated by the epigenetic silencing of the iron-responsive element binding protein 2 (IREB2) (Manz et al., 2016)
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