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It's enough to have a serious conversation with your rheumatologist, especially if you have RA plus excess weight, insulin resistance, or elevated cardiovascular risk
Because GLP-1RAs can mildly increase heart rate through autonomic activation, nanoparticle systems that localize drug delivery to vascular tissue may limit sinoatrial node exposure
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The peptide activates TGF-beta and VEGF signaling pathways, stimulating fibroblast proliferation, collagen I/III synthesis, and glycosaminoglycan production
(2) Optimizing combination therapy: traditional stepwise treatment may miss remission opportunities, whereas early triple therapy (e.g., metformin + GLP-1RA + SGLT2i) or targeted intensification strategies (e.g., SIIT followed by GLP-1RA) may maximize synergistic effects
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