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In most European markets, public systems and private insurance generally restrict funding of anti-obesity GLP-1 medicines, viewing them as high-cost with uncertain long-term value

DPP-4 inhibitors (sitagliptin, linagliptin): Generally not combined with GLP-1 agonists because they work on the same pathway with redundant mechanism

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It enhances the results of professional aesthetic treatments, making it a popular choice among dermatologists and aesthetic practitioners

This suggests that switching can restart weight loss, at least in one direction