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Deep Dive The Two New Gonorrhea Drugs Understanding the New Oral Gonorrhea Antibiotics The December 2025 approval of zoliflodacin and gepotidacin represents a paradigm shift in how healthcare providers can deliver gonorrhea treatment, offering patients unprecedented convenience and addressing the urgent threat of antibiotic resistant gonorrhea spreading globally. Zoliflodacin (Nuzolvence) How It Works Zoliflodacin belongs to an entirely new antibiotic class called spiropyrimidinetriones (SPTs), targeting bacterial DNA gyrasea type II topoisomerase enzyme essential for Neisseria gonorrhoeae survival

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