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Wiley Online Library This mechanism addresses a fundamental limitation of GLP-1R-only and GLP-1R/GIPR approaches: those compounds reduce energy intake primarily, but have limited ability to increase resting energy expenditure

Dose Titration Schedule Clinical trials established that starting with lower doses and gradually increasing reduces gastrointestinal side effects while maintaining long-term efficacy

Many women may aim for 70100g protein daily, depending on body size, goals, activity, and clinician guidance

Among them, 231 duplicate studies and 188 articles which did not meet the inclusion criteria were excluded

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