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Colchicine, Neomycin, Aminosalicylic Acid, H2-blockers (e.g., Ranitidine), and Proton Pump Inhibitors (PPIs, e.g., Omeprazole): These oral medications can all interfere with the intestinal absorption of dietary B12, making the need for injectable B12 more pronounced

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Because it dissolves in water, your body uses what it needs and passes much of the excess in urine

There is also a condition called pernicious anaemia where your immune system prevents the cells in your stomach and gut from absorbing B12 from your food