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As would be expected given these deficiencies in translation efficiency and fidelity, pre-leukemic Rps15 -mutated B cells exhibit decreased ribosome maturation and cellular proliferation (consistent with previous findings in HEK293T cells 34 ), as well as increased ROS and activation of DNA damage response, while also exhibiting proliferative cell signals (increased ZAP70 and Myc activation) (Fig

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In recent years, significant progress has been made in research on TAM-targeted strategies

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