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33,34,35,36 Adiponectin signaling pathway As a risk factor of asthma, obesity has been associated with increased airway inflammation, AHR, oxidative stress, inducible nitric oxide synthase (iNOS) expression, and elevated nitric oxide (NO) levels

In addition, pro-inflammatory cytokines , causing inflammation and muscle damage, can contribute to a decreased exercise performance

Therefore, to accurately assess the safety and efficacy of topical collagen peptidesparticularly those employing enhanced delivery systemswell-designed, randomized, double-blind, controlled clinical trials in humans are still required

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