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Confocal microscopy (CM) and TEM demonstrate that classically activated pro-inflammatory macrophage (LPS + IFN--induced) actively orchestrate a distinct spatial uncoupling between the ER and mitochondria, thereby enforcing the glycolytic metabolic switch requisite for robust inflammatory effector functions
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IAV infection increases the levels of xanthine oxidase, which is an enzyme responsible for oxygen-free radical generation in mouse serum and lung tissues, thus promoting disease pathogenesis 73
A differential regulatory T cell signature distinguishes the immune landscape of COVID-19 hospitalized patients from those hospitalized with other respiratory viral infections
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