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Recognizing Signs of GLP-1 Overdose or Overexposure Early warning signs that a semaglutide or tirzepatide dose exceeds your tolerance include persistent nausea lasting beyond the first week of a new dose, vomiting that prevents adequate nutrient intake, and inability to consume even small amounts of food or fluids without discomfort

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A sizable minority experience side effects like nausea

Abdomen injections The abdomen, specifically the area at least 2 inches from the navel, is the most common injection site