Mechanistically, there is a negative correlation between KLF2 and GPX4, and KLF2 deficiency increases the level of GPX4 and inhibits ferroptosis, promoting the invasion and migration of renal cancer cells, which can be reversed by overexpression of GPX4, 150 indicating that promoting ferroptosis of cancer cells may be a promising strategy for the clinical treatment of advanced RCC
But we do not completely know what happens when the previous pathological and longstanding balance is abruptly disturbed in different cascades of the chronic stress and reward system, involving leptin and ghrelin, GABA and dopamine, altogether with smoldering inflammation
Dizziness, dark urine or feeling faint on standing: dehydration
Neutral lipid storage disease: genetic disorders caused by mutations in adipose triglyceride lipase/PNPLA2 or CGI-58/ABHD5
I learned to enjoy balanced meals, stayed hydrated, celebrated small milestones instead of obsessing over the weighing scale, and made walking part of my daily routine