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doi: 10.1016/j.immuni.2020.11.006 177 KambayanaGSurya RiniS
It can shape a profoundly immunosuppressive TME by inducing the expansion of myeloid cells, enhancing the suppressive function of Tregs, or directly driving CD8 + T cells toward terminal exhaustion, thereby undermining the efficacy of various immunotherapies [292,293,294,295,296]
Inhibition of this site is associated with increased ROS production [62]
Its anti-inflammatory effects work through several mechanisms
Phytosterols like -sitosterol primarily act by interfering with cholesterol-dependent cell functions and oncogenic signaling
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