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USA 103 , 22572261 (2006)

Heavy Metals Toxicity: Mechanism, Health Effects, and Therapeutic Interventions

Once complexed with Cu(II), the peptide backbone rearranges into a specific square-planar coordination around the copper ion, with donor atoms from the glycine amino terminus, the deprotonated amide nitrogen, the histidine imidazole, and a fourth position (carboxylate or water depending on pH)

The most promising marker is calprotectin, because of its remarkable resistance to proteolytic degradation and its stability in stool kept at room temperature for at least seven days [169]

For example, DSIP has been shown to reduce sleep latency and increase the time spent in stage-3 sleep, aka SWS, in test animals