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The other consistent context in the preclinical literature is a metabolic environment the mouse studies pair the compound with diet/energy-balance conditions rather than testing it in isolation

The steady state values of GSH and other variables for different values of S are shown in Table 1

The classical redox pathways including WNT/-catenin, PI3K/AKT, NRF2, and p53 can respond to oxidant or antioxidant signals and significantly regulate gene transcription ( in vivo evidence supporting the osteogenic potential of NAC is promising, the inconsistency in its effects across different signaling pathways suggests a research gap

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