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Additionally, GLP-1RAs were able to address the pathophysiology of T2DM through an indirect mechanism also

While shifting fat from the liver, heart, muscle, kidneys and pancreatic beta cells to the superficial subcutaneous fat depots where it cannot cause harm does not increase weight, pioglitazone also activates peroxisome proliferatoractivated gamma receptors in the hypothalamus of the brain and sends a signal that the body needs to eat