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Injections that rely on prescription medications are sometimes the exception to this rule, but patients who fail to modify their diet and exercise regimen tend to quickly regain weight when they stop receiving the injections

In general, once a month is required to sustain results

Retatrutides Phase 2 monotherapy weight loss (~24.2% at 48 weeks) is numerically larger than cagrilintides (~10.8% at 26 weeks), but those come from different trials, durations, and doses, and cagrilintides strongest data are as the CagriSema combination

If a drug is administered by constant rate infusion (zero-order) it will accumulate to 50% of the steady state value after one half-life

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