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This is anecdotal, not peer-reviewed, but it suggests real-world effectiveness is comparable for many patients

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S., Ho, J-Y., Thomas, G

GLP-1 and Hypertension GLP-1 analogues LG and exendin-4 have been investigated in multiple models of hypertension

A frequently cited meta-analysis found berberine produced roughly four pounds of average weight loss, while semaglutide trials average around 15% of body weight