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Clin Endocrinol (2009) 71(4):5006
Incorporation of a trifluoromethyl group at the 6-position of the tetrahydropyran ring in omarigliptin (with a (2R, 3S, 5R, 6S) configuration) was found not only to enhance the pharmacokinetic profile in mice but also to maintain robust DPP-4 inhibitory activity
This study revealed a complex metabolic situation determined by insulin and palmitate in CACT-deficient cells, and has provided insight into the functional interactions between CACT, CPT1, malonyl-CoA, and acetyl-carnitine 59
Interestingly, intravenous injections of glutathione have been used for years but there is not even a single clinical trial evaluating its efficacy
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