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Nat Med 27(7):11541164
2.5 In vivo therapeutic effects of Ru SA+AC on ACLT-induced rat OA model Given the remarkable enzyme-like properties, mitochondrial protection, and anti-inflammatory effects demonstrated by Ru SA+AC in vitro, its therapeutic potentials for OA were further investigated based on rat models of OA induced by ACLT, followed by intra-articular injection of g-C 3 N 4 and Ru SA+AC nanozymes
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