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Deamidation Asparagine residues in peptides spontaneously convert to aspartate through a deamidation reaction, particularly at elevated temperatures and at neutral to basic pH
The NEJM authors reported the most common side effects as mild-to-moderate gastrointestinal events, with the trial discontinued due to adverse events in 4.4% to 7.8% of participants receiving orforglipron compared to 1.4% given the placebo
There are ups and downs, as well as adjustments, along the way
That said, severe or lasting pain is worth bringing up with your care team right away
Further details on the study design are published elsewhere 57
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