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Quinine should not be used for leg cramps due to FDA safety concerns
For patients with complex medical histories or who want a highly supervised program, an in-person clinic can be worth the added cost and effort
The STEP-1 trial measured outcomes at 68 weeks
With more approvals in use
High gastrointestinal discontinuation rates exceeding 50% across all doses, combined with liver safety signals in early studies, ultimately led Pfizer to discontinue danugliprons development in April 2025
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