L., Chandrasekhar, J., Madura, J
Although the aforementioned medications demonstrate some efficacy, their number is limited, and not all patients respond to them
Notwithstanding about the promising mechanisms of action, translation to patients is limited by bioavailability and pharmacokinetic issues, inter-subject variability and possible interactions with other chemotherapeutic agents or endocrine therapies highlighting the need for well-conducted randomised controlled trials and PKPD studies (248)
The bottom line on formulations If you are breastfeeding and your physician approves GLP-1 therapy, only injectable formulations should be considered
We previously demonstrated that a 1-week IGF-1 LR3 infusion into fetal sheep reduces in vivo and in vitro insulin secretion suggesting an intrinsic islet defect