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While exenatide provides clinically meaningful glycemic control, its impact on weight loss is relatively modest compared to more recent GLP-1R agents, resulting in less than 3 kg of weight reduction over a 30-week period (Min et al., 2025) necessitates twice-daily injections to maintain efficacy, which can be a limiting factor for long-term patient adherence

Factors That Influence Your First Month Outcome Your genetics, starting body composition, and adherence to the injection schedule all shape how much you lose in the opening month

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Melanotan II is a cyclic peptide analog of -MSH studied for its ability to bind melanocortin receptors , most notably MC1R (expressed on melanocytes) and MC4R (involved in appetite/behavior signaling)

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